Encapsulator B-390 / B-395

The BUCHI Encapsulator B-390 and B-395 Pro are laboratory-scale systems for the controlled encapsulation of active ingredients and biological materials. Based on vibrating nozzle technology, they generate highly uniform microbeads and core-shell microcapsules from hydrocolloid solutions, cell suspensions, drug formulations or reactive mixtures. The result is precise particle size distribution and gentle handling of sensitive materials – ideal for research and development in pharmaceuticals, life sciences, cosmetics, food and agrotech.

Key specifications:

• Capsule types: matrix beads and core-shell capsules

• Particle size range: 150 μm - 4 mm (80 - 2,000 μm standard)

• Productivity: 1 - 40 mL/min (min. 0.5 mL/min throughput)

• Vibration frequency: 40 - 6,000 Hz

• Reaction vessel capacity: 2 L (B-395 Pro)

• Single nozzles (0.08 - 1.00 mm) and concentric nozzles (0.2 - 0.9 mm)

• Special nozzles for viscous samples, sensitive cells and big capsules (2 - 4 mm)

Available models:

• Encapsulator B-390 – open-mode operation with nozzle heater for viscous samples

• Encapsulator B-395 Pro – open/sterile operation, available in standard and GMP variants with material certificates

Applications:

• Cell, bacteria and protein encapsulation

• Drug delivery and controlled-release pharmaceutical formulations

• Probiotic and nutraceutical encapsulation

• Functional food ingredients and flavor encapsulation

• Cosmetics, materials science and agricultural formulations