Mass spectrometry

BRUKER LC- and GC-Triple Quadrupole Mass Spectrometry: 

Triple quadrupole mass spectrometry (MS), also referred to as tandem mass spectrometry (MS/MS), is used to quantify components of a sample or to analyze their structure with increased specificity and sensitivity, by using two mass filtration steps in series, separated by a collision cell. Triple quad MS can detect both positive and negative ionizing compounds, increasing the range of components that get analyzed.

Due to its high sensitivity and specificity, which facilitate lower detection and quantitation limits, triple quad MS is a major tool in the fields of food testing, drug metabolism, pharmacokinetics, forensic toxicology, environmental studies, and biological analyses.

BRUKER QTOF Mass Spectrometry: 

Since its first commercial launch 25 years ago, quadrupole time-of-flight (QTOF) mass spectrometry (MS) has revolutionized numerous fields, ranging from biological and pharmaceutical research to clinical toxicology. The unique hybridization of quadrupole and TOF technology resulted in high-resolution, high mass accuracy analysis of all ions simultaneously, which is today used to identify and quantify complex mixtures or unknown compounds.

The MS/MS capabilities of QTOF MS systems enable coupling to both LC and GC systems and Bruker’s expertise provides a variety of innovative instruments. Our powerful, high performance products are specifically designed to meet the rapidly growing needs of customers in the academic, pharmaceutical, industrial, clinical, and applied markets.

BRUKER timsTOF – Trapped Ion Mobility Time of Flight Mass Spectrometry: 

Trapped Ion Mobility Spectrometry (TIMS) is an IMS technique where ions are propelled through the TIMS tunnel by a gas flow. An electrical field controls each ion from moving beyond a position defined by the ion’s mobility, where the push it experiences from the gas flow matches the force of the electrical field. Ramping down the electrical field allows selectively releasing ions from the TIMS tunnel according to their mobility.

By incorporating a TIMS device at the front of a quadrupole time-of-flight (QTOF) mass spectrometer, ions can be accumulated for a specific amount of time before being released for MS analysis. Using the PASEF® method, peptide ions are separated using TIMS, eluted (~ 100 ms) and detected in the QTOF, generating the TIMS MS heat map. In the PASEF® method, the same TIMS separation is used with the quadrupole isolating a certain ion species during its elution and immediately shifting to the next precursor. Parent and fragment spectra are aligned by mobility values.

TIMS

Trapped Ion Mobility Spectrometry (TIMS) is an IMS separation technique in gas phase, which resolves sample complexity with an added dimension of separation in addition to HPLC and mass spectrometry, increasing peak capacity and confidence in compound characterization. Equally as important, the TIMS device also serves to accumulate and concentrate ions of a given mass and mobility, enabling a unique increase in sensitivity and speed along with the additional dimension of separation.

A near 100% duty cycle for high sensitivity, high speed shotgun proteomics can now be achieved with the dual TIMS technology. The novel design allows for ions to be accumulated in the front section, while ions in the rear section are sequentially released depending on their ion mobility. This process is called Parallel Accumulation Serial Fragmentation, or PASEF®.

PASEF®

With speed in mind, Bruker experts redesigned MS/MS technology to meet the requirements of shotgun proteomics. With PASEF® technology >100 Hz sequencing speed can be achieved, and the MS/MS spectra quality of low abundant peptides can be increased by selecting them several times.

BRUKER MALDI-TOF and TOF/TOF MS

The analytical advantages of matrix assisted laser desorption ionization (MALDI) TOF MS have been demonstrated for more than 25 years. With inherent benefits including its speed (time to results) and application flexibility, the convenience and effectiveness of MALDI-TOF MS is magnified by virtue of its low sample volume requirements and broad sample content (salts, buffers) amenability. Dramatic increases in the depth of MALDI analyses have been made routine by intuitive software, and easy automation allows for high throughput solutions.

Bruker’s FLEX series instruments provide reliable results from a market leading technology platform - well-known for outstanding performance, reliability, convenience and innovative design. From rapid screening to comprehensive target characterization, MALDI-TOF MS offers broad utility to meet all laboratory needs. Expert users and beginners can quickly and confidently tap into the analytical power and flexibility of Bruker’s FLEX series MALDI-TOF systems.

BRUKER Magnetic Resonance Mass Spectrometry (MRMS)

MRMS is the pinnacle of mass spectrometry for both resolving power and mass accuracy

Bruker’s scimaX® and solariX series instruments are powered by MRMS (Magnetic Resonance Mass Spectrometry) technology. Compared with common FTMS technologies, these instruments feature unmatched eXtreme Resolution (XR) and mass accuracy. This enables routine Isotopic Fine Structure (IFS) analysis for a broad mass range, resulting in unmatched confidence for compound identification.

Inficon: 

Inficon is a leading provider of advanced spectroscopic instruments for gas analysis and materials characterization. Their instruments are widely used in semiconductor manufacturing, environmental monitoring, and research laboratories for precise measurements and quality control.

Magritek NMR

Benchtop NMR | NMR Spectroscopy without leaving your lab

Spinsolve is a revolutionary benchtop NMR spectrometer that provides exceptional performance in a compact package. It offers the highest sensitivity, resolution, and stability available for benchtop models and is equipped with an intuitive software that makes it easy and convenient to operate.