QqQ

BRUKER LC- and GC-Triple Quadrupole Mass Spectrometry: 

Triple quadrupole mass spectrometry (MS), also referred to as tandem mass spectrometry (MS/MS), is used to quantify components of a sample or to analyze their structure with increased specificity and sensitivity, by using two mass filtration steps in series, separated by a collision cell. Triple quad MS can detect both positive and negative ionizing compounds, increasing the range of components that get analyzed.

 

Due to its high sensitivity and specificity, which facilitate lower detection and quantitation limits, triple quad MS is a major tool in the fields of food testing, drug metabolism, pharmacokinetics, forensic toxicology, environmental studies, and biological analyses.

EVOQ LC-QqQ

Bruker EVOQ DART-TQ+ is the world's first triple quadrupole MS system built around a fully integrated Direct Analysis in Real Time (DART) ion source, so it runs chromatography-free screening and quantitation alongside conventional LC-MS on one platform. Plug-and-play DART operation with seamless source-parameter and automation control cuts cycle times from minutes to seconds, while the system still delivers best-in-class MRM speed of 1,000 MRMs per second and a scan rate up to 30,000 Da per second when conventional LC-MS is preferred. Removing chromatography from the workflow raises throughput, lowers operating cost and increases instrument uptime, with less solvent waste generated along the way.

Key features:

• Industry-first fully integrated, high-throughput DART ion source

• Chromatography-free screening and quantitation on the same platform as LC-MS

• Cycle times reduced from minutes to seconds

• 1,000 MRMs/second and scan rate up to 30,000 Da/second

• Plug-and-play DART operation with automated source control

Typical applications:

• High-throughput chromatography-free screening and quantitation

• Routine quality control requiring fast turnaround

• Laboratories running both DART-MS and conventional LC-MS workflows

EVOQ GC-QqQ

Bruker EVOQ GC-TQ is a gas chromatography triple quadrupole (TQ) mass spectrometer built as a comprehensive solution for the most demanding GC-MS/MS applications. Advanced electronics deliver high-speed MRM performance, while active ion-source focusing produces a robust, highly sensitive system that holds calibration over long analytical sequences. An elliptical ion-path design results in virtually zero neutral or chemical noise reaching the detector, and a high-capacity turbo pump is standard, giving unrivaled pumping performance for fast GC temperature ramps and high sample throughput.

Key features:

• Triple quadrupole (TQ) detector for demanding GC-MS/MS applications

• High-speed electronics for fast MRM acquisition

• Active ion-source focusing for robust, highly sensitive operation

• Elliptical ion-path design virtually eliminates neutral and chemical noise

• High-capacity turbo pump standard for unrivaled pumping performance

Typical applications:

• Trace-level quantitation in complex GC matrices

• Pesticide residue, environmental and food-safety analysis

• High-throughput routine GC-MS/MS laboratories

Chromatography free DART source

DART-MS (Direct Analysis in Real Time) is an ambient ionization source that enables rapid, versatile analysis directly on solids, liquids and gases in their native form, without chromatography or complex sample preparation. Samples ranging from concrete and currency to human skin can be analyzed as-is, cutting solvent usage by up to 90% and allowing laboratories to process up to 1,500 samples per day. Because there is no chromatographic separation step, DART-MS delivers results faster than conventional GC-MS or LC-MS workflows for screening-type analyses.

Key features:

• Ambient ionization directly on solids, liquids and gases in native form

• Chromatography-free — no complex sample preparation required

• Up to 90% reduction in solvent usage

• Throughput of up to 1,500 samples per day

• Faster results than conventional GC-MS or LC-MS for screening

Typical applications:

• Rapid screening of diverse sample types (surfaces, solids, liquids, gases)

• High-throughput quality control and forensic screening

• Applications where sample prep time and solvent cost must be minimized

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