Buchi Freeze dryer L 250

The BUCHI Lyovapor L-250 is a pilot-scale freeze dryer designed for gentle, energy-efficient lyophilization of biologically active samples in pharma, biotech, food and chemical R&D. Its EcoStream compressor design uses natural refrigerants for a very low global-warming impact (GWP index 4) while reaching a lowest condenser temperature of -85 °C. A modular manifold-and-shelf platform combined with Infinite-Control process software makes it easy to standardize methods and scale from feasibility studies to routine production.

Key specifications:

• Lowest condenser temperature: -85 °C

• Total condenser capacity: up to 5 kg ice

• Condensation rate: up to 4 kg / 24 h

• Manifold options: 12 or 24 connection positions

• Heated shelves (Pro): up to 60 ± 1 °C

• Endpoint detection: pressure (Basic) or pressure + product temperature (Pro)

• Sample formats: flasks, Falcon tubes, ampoules, metal trays

• Hot-gas defrosting, natural refrigerant (GWP 4)

• ACT Label certified for sustainability

Available models:

• L-250 Basic — manifold with non-heated shelves and pressure-based endpoint

• L-250 Pro — heated shelves, dual endpoint detection, product-temperature sensor and Sample Protective mode

Applications:

• Lyophilization of peptides, proteins and vaccines

• Preservation of biologically active pharmaceutical intermediates

• Food, nutraceutical and probiotic drying

• Chemistry R&D and formulation development

• Environmental sample stabilization