Freeze Drying

The BUCHI Lyovapor L-210 is a benchtop freeze dryer designed for gentle, reproducible lyophilisation of temperature-sensitive samples across pharmaceutical, biotech, food and academic laboratories. Infinite-Control technology provides a live graphical display of process parameters, automatic endpoint detection for primary and secondary drying, and sample-protection alarms - ensuring product integrity from freezing to final packaging. The ice condenser reaches -55 °C and holds up to 6 kg of ice, with a matched condensing performance of up to 6 kg per 24 hours, making the L-210 well suited to daily throughput of aqueous samples in flasks, vials, micro-titer plates or trays. A modular chamber concept - 12- or 24-port manifolds for flask work, and front-loading chambers with heated or non-heated shelves for vials, plates and trays - allows the same base unit to be tailored to the sample formats each laboratory actually uses, and to be reconfigured as needs evolve. An automatic hot-gas de-icing feature accelerates turnaround between runs, while the low-GWP refrigerant (GWP = 3) reduces the instrument's environmental footprint. The optional Pro sample-protection mode automatically pauses the process if the product temperature approaches the collapse threshold, protecting valuable proteins, peptides, biologically active compounds and formulated pharmaceutical intermediates from irreversible damage.

Key specifications:

• Lowest condenser temperature: -55 °C

• Ice condenser capacity: up to 6 kg

• Condensing performance: up to 6 kg per 24 h

• Refrigerant with a low Global Warming Potential (GWP = 3)

• Hot-gas de-icing for faster cycle turnaround

• Modular drying chambers: 12- or 24-port manifolds, front-loading chambers with heated or non-heated shelves

• Compatible with flasks, vials, micro-titer plates and trays

• Sample-protection mode (Pro version) triggered above the collapse temperature

Applications:

• Biotechnology: proteins, peptides, enzymes and antibodies

• Pharmaceutical formulation development

• Food and nutraceutical stabilisation

• Environmental and reference sample preservation

• Academic research and QC laboratories

The BUCHI Lyovapor L-250 is a pilot-scale freeze dryer designed for gentle, energy-efficient lyophilization of biologically active samples in pharma, biotech, food and chemical R&D. Its EcoStream compressor design uses natural refrigerants for a very low global-warming impact (GWP index 4) while reaching a lowest condenser temperature of -85 °C. A modular manifold-and-shelf platform combined with Infinite-Control process software makes it easy to standardize methods and scale from feasibility studies to routine production.

Key specifications:

• Lowest condenser temperature: -85 °C

• Total condenser capacity: up to 5 kg ice

• Condensation rate: up to 4 kg / 24 h

• Manifold options: 12 or 24 connection positions

• Heated shelves (Pro): up to 60 ± 1 °C

• Endpoint detection: pressure (Basic) or pressure + product temperature (Pro)

• Sample formats: flasks, Falcon tubes, ampoules, metal trays

• Hot-gas defrosting, natural refrigerant (GWP 4)

• ACT Label certified for sustainability

Available models:

• L-250 Basic — manifold with non-heated shelves and pressure-based endpoint

• L-250 Pro — heated shelves, dual endpoint detection, product-temperature sensor and Sample Protective mode

Applications:

• Lyophilization of peptides, proteins and vaccines

• Preservation of biologically active pharmaceutical intermediates

• Food, nutraceutical and probiotic drying

• Chemistry R&D and formulation development

• Environmental sample stabilization

The Zirbus Pilot Freeze Dryer series is designed for research, product development and small-scale production, made in Germany with fully customised solutions and 100%-recyclable stainless-steel construction. Depending on the unit size, these free-standing freeze dryers offer an ice-condenser capacity from 5 to 40 kg and a footprint of up to 2.7 m², with a compact design relative to that footprint. Every unit is equipped as standard with a vacuum valve for regulating the vacuum and a separating valve between the drying chamber and the condenser, and the entire cladding is made of stainless steel, making it resistant to all commercially available disinfectants.

Key features:

• Ice-condenser capacity from 5 to 40 kg depending on unit size (Sublimator 5/15/25/40)

• Footprint from 0.45 to 2.70 m² across the range

• Standard vacuum valve and drying-chamber/condenser separating valve

• Fully stainless-steel cladding, resistant to commercial disinfectants

• Made in Germany, with customised configuration options

Typical applications:

• Pilot-scale freeze drying for R&D and product development

• Small-scale production lyophilization

• Laboratories requiring compact, disinfectant-resistant freeze-drying units