KNAUER´s Ultra Low Dispersion Chromatography

KNAUER Ultra Low Dispersion Chromatography (ULDC) is an upgrade path for AZURA analytical HPLC systems that reduces internal system volume to sharpen peaks and improve separation. By optimising the injection, flow and detection components, ULDC narrows peak width and raises the signal-to-noise ratio, typically delivering a 20-30 % improvement over a standard configuration. Conventional methods transfer directly without redevelopment, so existing workflows keep running while elution becomes faster and sample throughput increases. Every AZURA system can be upgraded, making ULDC a cost-effective way to tune an installed AZURA 862 bar HPLC instead of replacing it.

Key specifications:

• Pressure: up to 862 bar, suitable for sub-2 um particle applications

• Gradient: binary, quaternary or isocratic configurations

• Detectors: UVD (VWD, MWD, DAD), RID, FLD, ELSD and MS

• Injection: 0.1-5000 ul, full loop, partial loop or microlitre pick-up

• Carry-over below 0.0003 % (chlorohexidine)

• LightGuide UV flow cells for high sensitivity

• Column switching for up to 4 columns plus bypass

• Software: knauerOS, ClarityChrom, Chromeleon, OpenLab or Mobile Control

Why ULDC:

• Reduced system volume improves peak shape, peak width and resolution

• Sharper peaks give better sensitivity and lower detection limits

• Faster elution shortens methods and raises sample throughput

• Existing conventional methods transfer without modification

• Any AZURA system can be upgraded, so no instrument replacement is needed

• Among the lowest environmental impact factors in the ACT database