Bruker MaXis II LC-qToF

maXis II is Bruker's market-leading ultra-high resolution LC-QTOF mass spectrometer, heralding a new era in accurate-mass LC-MS/MS with a full range of specified performance parameters delivered simultaneously in every run. Enhanced resolution and mass precision allow highly accurate determination of the monoisotopic masses of both light and heavy chains of monoclonal antibodies on an LC timescale, giving automated confirmation of product identity and detection of impurities. Superb raw data quality allows fast, easy detection of modifications such as deamidation in biotherapeutic characterization, without the time and cost of digesting and peptide-mapping the entire antibody. A dual ion funnel and orthogonal-acceleration TOF architecture give high sensitivity and resolving power across a wide range of LC and GC coupling options.

Key features:

• Ultra-high resolution and mass accuracy delivered simultaneously in every run

• Dual ion funnel with orthogonal-acceleration TOF architecture

• Fast, accurate biotherapeutic characterization without full peptide mapping

• T-ReX metabolomics workflow requiring no LC-MS/MS parameter optimization

• Curated contaminant and residue database covering over 3,000 compounds

Typical applications:

• Biopharmaceutical intact-mass and impurity characterization

• Non-targeted metabolomics and biomarker research

• Contaminant and residue screening in food, water and biological matrices