qTOF

The Bruker compact QTOF is a small, robust benchtop quadrupole time-of-flight mass spectrometer that provides unrivalled dynamic range together with mass accuracy, sensitivity, MS/MS performance and robustness in a single run. Great robustness to sample variation allows reduced sample pre-treatment, while low-picogram sensitivity delivers highly precise and reproducible MS and MS/MS data without the need for tuning or optimization. Five orders of magnitude intrascan dynamic range at UHPLC speed, combined with 50 GBit/second sampling technology, maintains full-specification resolution even during ultrafast chromatography, enabling definitive trace analysis from complex, high-background matrices.

Key features:

• Low-picogram sensitivity with highly precise, reproducible MS/MS data

• Five orders of magnitude intrascan dynamic range at UHPLC speed

• 50 GBit/second sampling technology for full resolution during ultrafast chromatography

• Superior 1 ppm mass accuracy via automated calibration

• True isotopic pattern for unambiguous spectra

Typical applications:

• Routine LC-MS/MS analysis in research and applied laboratories

• Trace-level analyte detection in complex, high-background matrices

• Compound identification and screening requiring accurate mass

The Bruker impact II VIP is an ultra-high resolution QTOF mass spectrometer delivering analytical performance for trace analysis in complex matrices, screening residues and contaminants and identifying impurities with higher confidence. Full sensitivity resolution exceeds 60,000, supported by a dual ion funnel and a choice of VIP-HESI, DART, GC-APCI and APPI sources plus a collision cell with broad mass transfer. Five orders of magnitude dynamic range at UHPLC speed, enabled by 50 GBit/second sampling technology, delivers definitive trace analysis from complex, high-background matrices, while intelligent self-optimizing MS/MS routines give one-shot acquisition with triple-quadrupole-level sensitivity in a single LC or GC run.

Key features:

• Full sensitivity resolution greater than 60,000

• Dual ion funnel with VIP-HESI, DART, GC-APCI and APPI source options

• Five orders of magnitude dynamic range at UHPLC speeds

• One-shot acquisition with triple-quadrupole-level sensitivity

• Intelligent self-optimizing MS/MS routines

• Switch between UHPLC, GC, CE and IC in under 10 minutes

Typical applications:

• Residue and contaminant screening in complex matrices

• Forensic and industrial/synthetic chemistry investigations

• Biomarker research and impurity identification

maXis II is Bruker's market-leading ultra-high resolution LC-QTOF mass spectrometer, heralding a new era in accurate-mass LC-MS/MS with a full range of specified performance parameters delivered simultaneously in every run. Enhanced resolution and mass precision allow highly accurate determination of the monoisotopic masses of both light and heavy chains of monoclonal antibodies on an LC timescale, giving automated confirmation of product identity and detection of impurities. Superb raw data quality allows fast, easy detection of modifications such as deamidation in biotherapeutic characterization, without the time and cost of digesting and peptide-mapping the entire antibody. A dual ion funnel and orthogonal-acceleration TOF architecture give high sensitivity and resolving power across a wide range of LC and GC coupling options.

Key features:

• Ultra-high resolution and mass accuracy delivered simultaneously in every run

• Dual ion funnel with orthogonal-acceleration TOF architecture

• Fast, accurate biotherapeutic characterization without full peptide mapping

• T-ReX metabolomics workflow requiring no LC-MS/MS parameter optimization

• Curated contaminant and residue database covering over 3,000 compounds

Typical applications:

• Biopharmaceutical intact-mass and impurity characterization

• Non-targeted metabolomics and biomarker research

• Contaminant and residue screening in food, water and biological matrices