Buchi Sepiatec SFC Systems

The BUCHI Sepiatec SFC Systems are supercritical fluid chromatography (SFC) platforms designed for fast, cost-efficient purification with dramatically reduced solvent consumption. Using supercritical CO2 as the primary mobile phase, the systems deliver superior separation power for chiral compounds, achiral small molecules and thermally labile substances - from milligram screening to multi-gram production.

Key specifications:

• Pressure: up to 400 bar

• Flow rate at 40 % modifier: 50 mL/min (SFC-50), 250 mL/min (SFC-250), 660 mL/min (SFC-660)

• UV detector: 190-720 nm (standard on all models)

• Optional ELSD and MS detection

• Integrated add-on pump: 30 mL/min on SFC-250; 250 mL/min on SFC-660

• Optional CO2 recycling on SFC-660

• Built-in column oven; single, multiple and stacked injection modes

Available models:

• SFC-50 - analytical to milligram scale, up to 10 columns with 4-16 mm ID and up to 250 mm length

• SFC-250 - semi-preparative gram scale, up to 10 columns with 15-30 mm ID and up to 250 mm length

• SFC-660 - production scale, single column up to 50 mm ID x 800 mm length, optional CO2 recycling

Applications:

• Chiral compound purification and enantiomer separation

• Pharmaceutical R&D and process development

• Natural product and cannabinoid isolation

• Fine and specialty chemistry purification

• Thermally labile compound separation with minimal solvent use