Bruker TimsTOF HT

Bruker timsTOF HT is powered by the 4th-generation TIMS-XR analyzer and advanced digitizer technology (ADT) for high-throughput 4D-Proteomics, delivering higher dynamic range and quantitation accuracy in cell and tissue proteomics work. PASEF technology reaches 300 Hz sequencing speed without compromising resolution or sensitivity, while the high charge capacity of the TIMS-XR analyzer extends analytical depth. The system is fully CCS-enabled and supports all PASEF acquisition modes, including PASEF, dia-PASEF and prm-PASEF, giving flexibility across 4D-Proteomics workflows, and the robust instrument design supports routine operation over thousands of samples without cleaning.

Key features:

• 4th-generation TIMS-XR analyzer with high charge capacity

• 300 Hz PASEF sequencing speed without loss of resolution or sensitivity

• Full support for PASEF, dia-PASEF and prm-PASEF acquisition modes

• CCS-enabled for higher dynamic range and quantitation accuracy

• Robust design for routine operation over thousands of samples

Typical applications:

• High-throughput 4D-Proteomics in cell and tissue biology

• Quantitative proteomics requiring high dynamic range

• Routine, high-volume LC-MS/MS proteomics workflows